Biomedical Image Processing / Medical Image Processing
Maryam Momeni; Hamid Abrishami Moghaddam; Reinhard Grebe; Kamran Kazemi; Fabrice Wallois
Volume 5, Issue 3 , June 2011, , Pages 231-244
Abstract
Reliable gradation of neonatal brain development is important for clinical investigation of neurological disorders. A prerequisite for such quantification of development is knowledge about an appropriate temporal resolvability. For this purpose, we investigated the evolution of macroscopic morphological ...
Read More
Reliable gradation of neonatal brain development is important for clinical investigation of neurological disorders. A prerequisite for such quantification of development is knowledge about an appropriate temporal resolvability. For this purpose, we investigated the evolution of macroscopic morphological features of the neonatal brain to estimate, for the first time, the required temporal interval in the early weeks after birth. In a first step, we constructed two neonatal templates for the age ranges of 39-40 and 41- 42 weeks' gestational age using T1-weighted MR images. We compared the spatial variation of anatomical landmarks and the average and the maximal length of spatial deformation in 25 subjects normalized to the two templates along x, y and z directions. MANOVA confirmed the significant difference between spatial variations of the above macroscopic features in the two age ranges. Furthermore, quantitative analysis of feature scattering yielded the same result even in features for which the null hypothesis was not rejected by MANOVA. We conclude that minimal temporal interval of two weeks is required for acute macroscopic morphological studies of the developing brain in the early weeks after birth.
Biomedical Image Processing / Medical Image Processing
Hamid Abrishami Moghaddam; Maryam Momeni; Kamran Kazemi; Reinhard Grebe; Fabrice Wallois
Volume 4, Issue 4 , June 2010, , Pages 337-360
Abstract
Diagnostic follow-up of the brain development during the neonatal period and childhood is an important clinical task. Any disturbance of this process can cause pathological deviations, especially if the baby is born premature. Recent advances in magnetic resonance imaging allow obtaining high-resolution ...
Read More
Diagnostic follow-up of the brain development during the neonatal period and childhood is an important clinical task. Any disturbance of this process can cause pathological deviations, especially if the baby is born premature. Recent advances in magnetic resonance imaging allow obtaining high-resolution images of the neonatal brain. After segmenting the brains they can be used to reconstruct and model changes occurring during neonatal brain development. In addition such near-realistic model of the head, including the skin, skull and brain can be used to solve the inverse problem of determining the sources of registered signals from electrical brain activity. Although there exist numerous methods and various modeling schemes for adults, these cannot be used directly for neonates due to important differences in morphology. In this review article, neonatal brain atlases are divided into three categories: individual atlases, probabilistic atlases and stochastic atlases. In the following, existing neonatal brain atlases are placed in this classification and their methods of construction are presented. Furthermore, strengths and weaknesses of those neonatal brain atlases are analyzed and finally future research trends in this area are explained.
